Faculty/Research
Berman, Doreen, Ph.D.
Bodnar, Richard J., Ph.D.
Borod, Joan C., Ph.D.
Bruder, Gerard, Ph.D.
Brumbaugh, Claudia, Ph.D.
Brumberg, Joshua, Ph.D.
Croll, Susan D., Ph.D.
Ehrlichman, Howard, Ph.D.
Farrell, William, Ph.D.
Fields, Lanny, Ph.D.
Flory, Janine, Ph.D.
Foldi, Nancy, Ph.D.
Foxe, John, Ph.D.
Golub, Sarit, Ph.D.
Gomes, Hilary, Ph.D.
Halperin, Jeffrey, Ph.D.
Hinton, Veronica, Ph.D.
Johnson, Ray, Jr., Ph.D.
Kest, Benjamin, Ph.D.
Kluger, Alan, Ph.D.
Li, Andrea, Ph.D.
Lizardi, Humberto, Ph.D.
Pytte, Carolyn L., Ph.D.
Rabin, Laura, Ph.D.
Ranaldi, Robert, Ph.D.
Ravdin, Lisa, Ph.D.
Sclafani, Anthony, Ph.D.
Sneed, Joel, Ph.D.
Sturmey, Peter, Ph.D.
Walder, Deborah, Ph.D.
Genetic Variance in Ingestive Responses
The role of genetic variance in ingestive responses has been primarily studied by systematically comparing different inbred strains of mice with an outbred strain. In successive collaborations with Drs. Benjamin Kest (College of Staten Island) and Anthony Sclafani (Brooklyn College), our laboratory characterized the sensitivity, potency and magnitude of responses of 11 inbred (A/J, AKR/J, BALB/cJ, CBA/J, C3H/HeJ, C57BL/6J, C57BL/10J, DBA/2J, SJL/J, SWR/J, 129P3/J) and one outbred (CD-1) mouse strains for sucrose and fat (Intralipid) intake as well as for intake following regulatory glucoprivic (2-deoxy-D-glucose) and lipoprivic (mercaptoacetate) challenges. Our laboratory has also examined alterations in sucrose and Intralipid intake in eight (BALB/cJ, C3H/HeJ, C57BL/6J, C57BL/10J, DBA/2J, SJL/J, SWR/J, 129P3/J) and one outbred (CD-1) mouse strains following opioid and dopamine D1 and D2 receptor antagonism. Ongoing studies are examining whether genetic variance occurs for the development and strength of conditioned flavor preferences.
Genetic Variance Publications of the Bodnar Laboratory:
Dym, CT, A Pinhas, M Robak, A Sclafani and RJ Bodnar. Genetic variance contributes to dopamine D1 and D2 antagonist-induced inhibition of sucrose intake in inbred and outbred mouse strains. Brain Res., in final preparation, 2008.
Bodnar, RJ, SR Lewis and B Kest. Section 3.3: Feeding and drinking, Section 3: Autonomous and motor behaviors, Volume I: Behavioral Genetics of the Mouse. In: Encyclopedia of Behavior Genetics, WE Crusio, F Sluyter and RT Gerlai (Eds.) Cambridge University Press: Cambridge, United Kingdom, in press, 2008.
Dym, CT, A Pinhas, M Ginzberg, B Kest and RJ Bodnar. Genetic variance contributes to naltrexone-induced inhibition of sucrose intake in inbred and outbred mouse strains. Brain Res. 1135: 136-145, 2007.
Lewis, SR, C Dym, C Chai, A Singh, B Kest and RJ Bodnar. Genetic variance contributes to ingestive processes: a survey of eleven inbred mouse strains for fat (Intralipid) intake. Physiol. Behav. 90: 82-94, 2007.
Lewis, SR, C Dym, M Ginzberg, B Kest and RJ Bodnar. Genetic variance contributes to ingestive processes: a survey of mercaptoacetate-induced feeding in eleven inbred and one outbred mouse strains. Physiol. Behav.88: 516-522, 2006.
Lewis, SR, S Ahmed, E Khaimova, Y Israel, A Singh, Y Kandov, B Kest and RJ Bodnar. Genetic variance contributes to ingestive processes: a survey of 2-deoxy-D-glucose-induced feeding in eleven inbred mouse strains. Physiol. Behav. 87: 595-601, 2006.
Lewis, SR, S Ahmed, C Dym, E Khaimova, B Kest and RJ Bodnar. Inbred mouse strain survey of sucrose intake. Physiol. Behav. 85: 546-556, 2005.